As with any anabolic steroid, many are concerned with the associated side effects that do end up Winstrol side effects being associated with it, and of course Winstrol does come with its particular side effects that must be known to the reader.
I have mentioned already that Winstrol is not associated with any estrogenic-related side effects due to its ability to avoid interaction with the aromatase enzyme. Therefore, we can discount any possibility of estrogen related side effects. These include: gynecomastia (breast tissue growth), water retention, fat retention, blood pressure increases, etc.
However, we cannot dismiss the possibility of androgenic side effects for females, and even for males. The first obvious list of to state is that for females, the possibility of developing male characteristics exists. Remember that Winstrol is a DHT-derived anabolic steroid, granting it some quite androgenic strength. Should females use this substance, they must be aware of the possibility of: facial hair growth, deepening of the voice, and clitoral enlargement. Virilisation-type side effects do exist for males as well, and men may experience: increased propensity for acne, increased possible oily skin, body hair growth, and of course the increased risk of male pattern baldness if the person does possess the genetic trait for such a condition.
Hepatotoxicity (liver toxicity) is an issue with Winstrol in both its injectable as well as oral formats. I have discussed this at the beginning of the article and touched upon it several times since, so this should be fairly familiar to you. In order for anabolic steroids to be bioavailable in an oral form, they must be modified at the 17th carbon with an alkyl group. This is known as C17 alpha alkylation. Though this allows the anabolic steroid to pass through the liver unchanged, it also places a certain amount of stress on the liver due to its resistance to breakdown. Unfortunately, Winstrol is one of the only anabolic steroids in which both the injectable as well as the oral formats contain this structural modification, thereby causing it to be more or less equally as hepatotoxic in both formats (even though the injectable avoids the ‘first pass’ through the liver). However, with this being said, it has been known that Winstrol on a milligram for milligram bases, does have less liver toxicity and stress than other comparable oral anabolic steroids such as Anadrol-50 or Dianabol. However, possible liver dysfunction should still be a concern, and it is advisable that Winstrol be run for no longer than 6-8 weeks of the oral form, and an utmost maximum of 10 weeks with the injectable. I would advise to keep either as short as possible on the minimum end. It is also a good idea to use a solid liver support supplement while using oral anabolic steroids in order to minimize risks. Proper bloodwork before, during, and after the cycle is advised in order to keep a close eye on liver enzyme readings. Should readings rise rapidly and end up in the danger zones, one should immediately stop the cycle and seek liver health treatment.
Negative cardiovascular side effects exist with all anabolic steroids, and there is no exception here with Winstrol. In fact, due to the issue that Winstrol is an oral anabolic steroid (thanks to its C17 alpha alkylation), cholesterol level disruptions are even more prominent. This goes for any anabolic steroid that is modified in such a manner for oral consumption. The C17 alkylation not only presents hepatotoxicity, but because it is doing so, the liver, which controls cholesterol production, ends up being affected. As a result, the increase of LDL (bad cholesterol) to HDL (good cholesterol) changes for the worse, and higher levels of LDL result. Anabolic steroids themselves without these oral modifications already have a propensity for increasing LDL levels at supraphysiological doses, and when the oral modifications are taken into account, this becomes even worse. The risks associated with these negative changes are arteriosclerosis, and increased strain on the heart and cardiovascular system as the blood must require even more effort to be pumped through increasingly thick and viscous cholesterol. It is very important to supplement with good fats and fish oils on cycle, and to take a cardiovascular support supplement of some sort in order to positively influence cholesterol levels to favour HDL levels being higher than LDL levels. Once anabolic steroid administration is discontinued, it is important for the reader to understand that unless some sort of proactive change is made in the nutritional sense (as I mentioned in the prior sentence), cholesterol levels will remain negatively affected for weeks following an anabolic steroid cycle! Proactive changes to diet in order to support healthy cholesterol levels on-cycle while using any anabolic steroid is a massive ‘must’ for any user.
Lastly, as with any anabolic steroid, administration of androgenic anabolic steroids will suppress and/or shut down endogenous Testosterone production in the body. Prolonged use and/or higher doses will influence this more and more negatively until the body will not produce any more of its own Testosterone levels. The user in question should, upon cessation of any anabolic steroid cycle, utilize Testosterone and gonadotropin stimulating drugs in order to recover their natural endogenous testosterone production as quickly as possible. Failure to do so can result in permanent damage to the body’s own testosterone production in the long term.